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KMID : 1123920050190051337
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Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 5 p.1337 ~ p.1343
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Preventive Effect of A Chafer, Protaetia brevitarsis Extract on Carbon Tetrachloride-Induced Liver Injuries in Rats
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Hwang Seock-Yeon
Kim Yun-Bae
Lee Sang-Han
Yun Chi-Young
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Abstract
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The hepato-protective effects of the extract from Protaetia brevitarsis against hepatotoxicity by carbon tetrachloride () were studied in rats. The rats were orally treated with (50% in corn oil) at initial dose of followed by four times during 2-week period. The extract of P. brevitarsis (50, 100 or 200 mg/kg) or its vehicle was administered day after day from 1 week before Injection during five weeks. induced hepato-celluar degeneration and necrosis induced to increase in serum aspartate amintransferase (AST) and alanine aminotransferase (ALT) levels. In biochemical analyses, thiobarbituric acid-reactive substances (TBARS) and antioxidant enzymes such as superoxide dismutase (SOD) and catalase in hepatic tissues were remarkably increased by treatment. Not only increases in serum AST and ALT, but also induction of lipid peroxidation and antioxidant enzymes in hepatic tissues caused by were significantly attenuated by the P. brevitarsis extract in a dose-dependent manner. Such hepato-protective effects of P. brevitarsis extract were confirmed by histopathological examinations, wherein only mild hepatocytic vacuolations were observed in the liver of rats treated with a high dose (100 mg/kg) of P. brevitarsis extract in comparison with severe hepatocytic degenerations administered with alone. From these results, it is suggested that the extract of Protaetia brevitarsis could be a promising candidate for the protection of liver injury, based on the preventive effects against morphological cellular injuries, lipid peroxidation and serum biochemical parameters.
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KEYWORD
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Protaetia brevitarsis, Preventive effect, Hepatotoxicity, Carbon tetrachloride
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